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Research area(s)

The principle focus of my research is elucidate and understand the complex roles played by immune cells in vascular inflammation and thrombosis. The aim of my research it to design tailored next generation therapeutics for inflammatory pathologies that temper inflammation and enhance resolution.

Within the continuum of an inflammatory response, the objective of my research is to study the role of the microvasculature as a dynamic-interface between circulating blood cells and immune cells (such as neutrophils and platelets) and tissue. My lab focuses on how circulating cells communicate, adhere and migrate across the endothelium and the pathways by which these circulating and resident cells can render systemic inflammatory responses and alter local inflammatory and thrombotic states. By targeting the pathophysiology of endogenous pro-resolving pathways such as the Annexin A1-Formyl Peptide Receptor (AnxA1-FPR) pathway, we hope to identify novel and innovative anti-inflammatory therapeutics for the treatment of cardiovascular and cerbrovascular diseas

The research in my laboratory crosses the boundaries between Integrative physiology and pharmacology and uses multidisciplinary approaches to advance understanding of the vascular physiology and pathophysiology of inflammatory and related disorders, at the molecular, cellular, tissue and whole organism levels. To achieve this goal, we use a technological toolbox compromising of various experimental in-silico, in-vitro and in-vivo systems and advanced imaging modalities (including confocal intravital microscopy, magnetic resonance imaging [MRI]; positron emission tomography [PET], and in-vivo imaging systems [IVIS]), coupled with multi-omics approaches to dissect the contribution of neutrophils and platelets in inflammation, thrombosis and vascular dysfunction. 

Research Interests

• Inflammation
• Thrombosis (arterial and venous)
• Resolution of inflammation
• Immune mediated responses in normal and pathological conditions
• Neutrophil-Platelet interactions
• Ischaemia reperfusion injury (I/RI)
• Healthy ageing
• Formyl Peptide Receptors (FPRs)
• Annexin A1 Biology
• Sickle Cell Disease
• Inflammation in Cancer
• Pre-clinical imaging
• Drug discovery and resolution biologics
• Novel drug delivery systems e.g Nanocarriers

Grants