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Research area(s)

Design novel adoptive cell therapies, Drug Discovery and Development, Characterisation of immune cell subsets , Disease Immuno-monitoring, Multiparametric Flow Cytometry and Deep-immunophenotyping, Regulatory T Cell Manipulation, Design and production of CAR-T cells

Research Interests

Cristiano Scottà's current research within the Centre for Inflammation Research and Translational Medicine (CIRTM) focuses on understanding the regulatory processes behind pathological inflammatory conditions and manipulating human regulatory T cells (Tregs) to develop novel cellular therapies for controlling immune-mediated inflammatory diseases.

His work is structured around five main objectives:

1. Understanding Treg Heterogeneity: Investigating the diverse subpopulations of Tregs to identify therapeutic targets, particularly in conditions like atherosclerosis, pregnancy, and systemic lupus erythematosus.
2. Enhancing Treg Clinical Efficacy: Exploring molecular mechanisms, such as FOXP3 acetylation/ubiquitination, to improve Treg stability and function in inflammatory settings.
3. Investigating Treg Cells Function in Pregnancy Complications: Exploring the role of Tregs during pregnancy complications such as preeclampsia and gestational diabetes.
4. Studying Treg Cell Crosstalk with Other Immune Cells in Cardiovascular Disease: Exploring the role of Tregs in mitigating endothelial cell dysfunction and progression of atherosclerosis.
5. Producing Novel Therapeutic Treg Products: Developing new therapeutic approaches, including CAR-Tregs, to treat inflammatory disorders. Current research focuses on treating skin inflammation and regulating B cell responses by controlling autoantibody production.

Together, these objectives aim to translate innovative immunological insights into targeted, effective treatments for chronic inflammatory diseases.

Grants