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Research Interests

Dr Sabrina Tosi is the Head of the Leukaemia and Chromosome Research Laboratory. Her research focuses on the contribution of chromosomal abnormalities to leukaemia. Dr Tosi has a particular interest towards the study of childhood leukaemia. This interest dates back to 1989, when she started her scientific career soon after her undergraduate studies. The main methodological approach used in the laboratory involves the application of modern molecular cytogenetic techniques to unravel the genetic changes at the basis of leukaemic transformation. The projects currently ongoing in the lab are based on the use of fluorescence in situ hybridisation (FISH), immunofluorescence and microscopy. These methods have enabled the characterization of new non-random chromosomal translocations specifically associated with certain leukaemia subtypes. Dr Tosi’s research interests extend to view chromosomal alterations in context with the higher order chromatin organisation and expression patterns.

Grants

Project details

• Kidscan PhD studentship (2017) Modelling the t(7;12) infant leukaemia using gene editing technology. S. Tosi, A. Sala, G. Santilli, £40,110 awarded for 3 years.
• Kidscan Pump Priming Grant Scheme (2016) Investigating the potential role of CHD1L, a chromatin-remodelling factor involved in the DNA damage response, in childhood neuroblastoma. C. Cooper, S. Tosi, A. Sala, £5,000 awarded for 12 months.
• Interschool project grant no. LBA006 (2009)Analysis of Chromosome Imbalances Using a-CGH Microarray Images. S. Tosi, Y. Li, SJL Knight, £2,500 awarded for 6 months
• Interschool project grant no. LBA007 (2009) Investigating the function of the Homeobox Gene HLXB9 and its role in Leukaemiausing a combined Biochemical and Computational Systems Biology Approach. S. Tosi, D. Gilbert, Q. Gao, J. Hughes, £2,500 awarded for 6 months
• BRIEF award (2005-2006) Alterations of the nucleoporin 98 gene in leukaemia: incidence and functional studies. S. Tosi, £15,000 awarded for 1 year.
• Leukaemia Research Fund UK grant no. 0253 (2003- 2006) Development and application of a CGH microarray system for the assessment of chromosome imbalances in patients with myeloid disorders and apparently normal karyotype, Dr. J. Boultwood, Dr. S. Tosi, Dr. S.J.L. Knight, Professor J.S. Wainscoat, Professor K.C. Gatter, £107,346 awarded for 3 years.
• Leukaemia Research Fund UK grant no. 0354 (2003- 2006) Investigation of recurrent chromosomal imbalances in Hodgkin lymphoma using a CGH microarray system, Professor R. Jarrett, Dr. S. Tosi, Dr. SJL Knight. £ 157,457 awarded for 3 years.